Sterols and the reductant nicotinamide adenine dinucleotide phosphate (NADPH), essential for eukaryotic life, arose because of, and as an adaptation to, rising levels of molecular oxygen (O2). Hence, the NADPH and O2‐intensive process of sterol biosynthesis is inextricably linked to redox status. In mammals, cholesterol biosynthesis is exquisitely regulated post‐translationally by multiple E3 ubiquitin ligases, with membrane associated Really Interesting New Gene (RING) C3HC4 finger 6 (MARCHF6) degrading at least six enzymes in the pathway. Intriguingly, all these MARCHF6‐dependent enzymes require (...) NADPH. Moreover, MARCHF6 is activated by NADPH, although what this means for control of cholesterol synthesis is unclear. Indeed, this presents a paradox for how NADPH regulates this vital pathway, since NADPH is a cofactor in cholesterol biosynthesis and yet, low levels of NADPH should spare cholesterol biosynthesis enzymes targeted by MARCHF6 by reducing its activity. We speculate MARCHF6 helps mammalian cells adapt to oxidative stress (signified by low NADPH levels) by reducing degradation of cholesterogenic enzymes, thereby maintaining synthesis of protective cholesterol. (shrink)

It is introduced a new algebra$$(A, \otimes, \oplus, *, \rightharpoonup, 0, 1)$$(A,⊗,⊕,∗,⇀,0,1)called$$L_PG$$LPG-algebra if$$(A, \otimes, \oplus, *, 0, 1)$$(A,⊗,⊕,∗,0,1)is$$L_P$$LP-algebra (i.e. an algebra from the variety generated by perfectMV-algebras) and$$(A,\rightharpoonup, 0, 1)$$(A,⇀,0,1)is a Gödel algebra (i.e. Heyting algebra satisfying the identity$$(x \rightharpoonup y ) \vee (y \rightharpoonup x ) =1)$$(x⇀y)∨(y⇀x)=1). The lattice of congruences of an$$L_PG$$LPG-algebra$$(A, \otimes, \oplus, *, \rightharpoonup, 0, 1)$$(A,⊗,⊕,∗,⇀,0,1)is isomorphic to the lattice of Skolem filters (i.e. special type ofMV-filters) of theMV-algebra$$(A, \otimes, \oplus, *, 0, 1)$$(A,⊗,⊕,∗,0,1). The variety$$\mathbf {L_PG}$$LPGof$$L_PG$$LPG-algebras (...) is generated by the algebras$$(C, \otimes, \oplus, *, \rightharpoonup, 0, 1)$$(C,⊗,⊕,∗,⇀,0,1)where$$(C, \otimes, \oplus, *, 0, 1)$$(C,⊗,⊕,∗,0,1)is ChangMV-algebra. Any$$L_PG$$LPG-algebra is bi-Heyting algebra. The set of theorems of the logic$$L_PG$$LPGis recursively enumerable. Moreover, we describe finitely generated free$$L_PG$$LPG-algebras. (shrink)

Kripke and Putnam have proposed that terms may be introduced to refer to theoretical entities by means of causal descriptions such as 'whatever causes observable effects O'. It is argued that such a reference-fixing definition is ill-formed and that theoretical beliefs must be involved in fixing the reference of a theoretical term. Some examples of reference-fixing are discussed e.g., the term 'electricity'. The Kripke-Putnam theory can not give an account of how terms may be introduced into science and then subsequently (...) be discovered to be non-referring. A modified account of reference-fixing is suggested in which terms such as Gilbert's electric effluvia' and 'phlogiston' can be introduced into science and then be found to lack a reference. (shrink)

In this paper we study and equationally characterize the subvarieties of BL, the variety of BL-algebras, which are generated by families of single-component BL-chains, i.e. MV-chains, Product-chain or Gödel-chains. Moreover, it is proved that they form a segment of the lattice of subvarieties of BL which is bounded by the Boolean variety and the variety generated by all single-component chains, called ŁΠG.

This book brings together scholars from a variety of epistemological perspectives to explore the multiple ways in which sexuality does indeed matter in the arena of public education.

Research involving minors has been the subject of much ethical debate. The growing number of longitudinal, pediatric studies that involve genetic research present even more complex challenges to ensure appropriate protection of children and families as research participants. Long-term studies with a genetic component involve collection, retention and use of biological samples and personal information over many years. Cohort studies may be established to study specific conditions (e.g. autism, asthma) or may have a broad aim to research a range of (...) factors that influence the health and development of children. Studies are increasingly intended to serve as research platforms by providing access to data and biological samples to researchers over many years. (shrink)

Tensions between idealism and scientific realism have been resolved by an appeal to the theory/observation distinction. but many who support incommensurability reject the distinction in favor of a version of idealism, e.g., thomas kuhn who supports a version of relativist idealism in which the terms of a theory do refer, but only to a paradigm--relative world of entities. it is argued that the three kinds of idealism depend on a cluster theory of meaning for fixing the reference of scientific terms, (...) and that a realist interpretation of the growth of science must eschew such a theory of meaning. the kripke-putnam theory for reference fixing of theoretical terms is employed to show how one term, 'mass', is referentially invariant despite change in the theory of motion from newton to einstein. (shrink)

These three volumes are amongst the first of a series of anthologies of philosophical writings under the title Oxford Readings in Philosophy, the series editor being G J Warnock. The blurb on the back of each says that ‘the aim of this series is to bring together important recent writings in major areas of philosophical inquiry, selected from a variety of sources, mostly periodicals, which may not be conveniently available to the university student or the general reader’. But all good (...) anthologists have at least this in mind. Hence the glut of anthologies and the reduplication of articles belying the aims of anthologists. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Philosophy and Rhetoric 36.3 (2003) 207-222 [Access article in PDF] Burke Contra Kierkegaard:Kenneth Burke's Dialectic via Reading Søren Kierkegaard G. L. Ercolini Isaac—to his children Lived to tell the tale— Moral—with a Mastiff Manners may prevail. —Emily Dickinson Kenneth Burke employs the term dialectic throughout his works and yet, despite its profuse recurrence, the term remains ambiguous. Much secondary scholarship has focused on Burke and dialectics, and still the (...) term in Burke remains—if not already complicated—cloudy. 1 Part of the difficulty regarding this term stems from Burke's own ambiguity; another part from critics' tendency to rely on Burke's own use and definitions for clarification of this concept. The arguments have been helpful and illuminating, yet Burke's dialectic can be further clarified by going beyond what Burke means by the term by focusing on how he deploys dialectical criticism in his own work. 2 This article focuses on Burke's appropriation of the existential thinker Søren Kierkegaard as a particularly clear and remarkable instance of the operation of Burke's dialectic in his criticism. I maintain that although Burke's reading of Kierkegaard is arguably a misreading, his strategic appropriation of Kierkegaard in A Rhetoric of Motives (1950) not only serves as a clear deployment of the dialectic, but also functions as a foil against which Burke defines his own critical method. Burke's reading of Kierkegaard emphasizes the function of resolution in Burke's critical project.The current literature, although quite informative, does not put Burke's dialectic in sharp focus. Rueckert argues that Burkean dialectics "is really a branch of what Burke was to later call logology, the study of words, of language, of symbol systems" (1994, 14). Heath claims that dialectic "is an analytical tool to help us diagnose perspectives so that we can [End Page 207] examine whether they make sense and consider their implications for social relations" (1986, 162). Crusius contends that, "dialectic for Burke is the study of verbal universes, the disinterested pursuit of a vocabulary's implications" (1986, 24). While Brummett and Crusius show similarity between Hegel's and Burke's dialectic, Heath and Wess distinguish Burke's dialectic from Hegelian idealism and teleological history respectively. 3 Most of the arguments concerning Burke and dialectic focus on "The Dialectic of Constitutions" in A Grammar of Motives (1969), while A Rhetoric of Motives (1962), where Burke identifies humankind as homo dialecticus, is hardly engaged with regard to this concept. 4 Burke's working through Kierkegaard in A Rhetoric of Motives demonstrates Burke's dialectical criticism—thus providing an operational account of Burke's dialectic—and allows for his revelation of the three motives in the realm of rhetoric: the Order, the Secret, and the Kill. 5 And yet, despite this centrality of Fear and Trembling, surprisingly little has been said about Burke's Kierkegaard beyond passing mention. 6Despite editorial advice to the opposite regarding an article that would later become a part of the book, Burke evidently regarded his reading of Kierkegaard as important. Joseph Bennett, editor of Hudson Review, responded as follows to Burke's 1948 submission of the article entitled "Imagery of Killing": "I would like to request that you eliminate Kierkegaard from the article in question, confining it simply to literary exegesis and excluding the philosopher theologian." 7 Although he complied for the article, Burke retained his reading of Kierkegaard in A Rhetoric of Motives. Despite the lack of attention given to it, Burke's engagement with Kierkegaard clearly demonstrates how Burke views ethical criticism as that which resolves opposition, negation, and paradox to a higher order. Burke contra Kierkegaard The section entitled "Order" in A Rhetoric of Motives contains a detailed, twenty-three-page discussion of Kierkegaard's Fear and Trembling. In this discussion, Burke primarily attacks Kierkegaard for encouraging what Burke enigmatically and elliptically identifies as the "cult of the Kill."Burke's portrayal of Kierkegaard is hardly flattering: at the crescendo of his analysis in A Rhetoric of Motives he claims that thinking such as Kierkegaard... (shrink)

The global economic crisis, the popular discontent against traditional parties and post-democratic forms of governance, as well as the sharp increase in migrant and refugee arrivals have led to the resurgence of populist parties around the world. Left-wing parties usually express an inclusionary populist discourse with patriotic features, while right-wing parties utilize an exclusionary populism with strong nationalist and xenophobic characteristics. In Greece in recent years, the radical left party of SYRIZA rose to power through a left-wing populist and anti-imperialist (...) discourse. Alexis Tsipras formed a paradox coalition government with the radical right party of ANEL to reach an agreement that would lessen the effects of austerity policies. However, once in office, SYRIZA transformed some features of its political style and began to follow a type of "pragmatic populism". This paper examines the relationship between populism and anti-imperialism, while analyzing SYRIZA's discourse in opposition and in power. The questions that it attempts to answer are: does Tsipras express an anti-imperialist discourse both in opposition and in power? What forces are considered imperialist by SYRIZA? Can the notion of "crypto-colonialism" explain the rise of left-wing populism in Greece? (shrink)

How far can we construct a framework within which to compare different traditions of philosophy and science across civilizations? The first problem lies with the terms “philosophy” and “science” themselves, for they carry particular associations in Western thought, some of which contribute to the mistaken view that they are uniquely Western activities. This brief article refutes that view, examining how we can compare the philosophical and scientific achievements of different cultures, and further challenging the sharp positivist dichotomy between “science” and (...) “philosophy” that stems from equating the former with facts, the latter with values. (shrink)

How far can we construct a framework within which to compare different traditions of philosophy and science across civilizations? The first problem lies with the terms “philosophy” and “science” themselves, for they carry particular associations in Western thought, some of which contribute to the mistaken view that they are uniquely Western activities. This brief article refutes that view, examining how we can compare the philosophical and scientific achievements of different cultures, and further challenging the sharp positivist dichotomy between “science” and (...) “philosophy” that stems from equating the former with facts, the latter with values. (shrink)

Among the abilities people fear they will lose as they age, the most frequently reported is "staying sharp". The fear of being afflicted with Alzheimer's disease and other dementing disorders, which will clinically impact 10 to 12% of the population between the age of 65 and death, is the major concern. Despite the fear of losing their minds, most persons will not develop Alzheimer's disease. So why does the fear of losing mental acuity top the AARP list?One reason is that (...) older adults in general cannot distinguish the usual changes with aging from neurocognitive disorders such as Alzheimer's disease. We also live in a society that has been labeled, among other things... (shrink)

Clinical Study Agreements can have profound effects both on the protection of human subjects and on the independence of investigators to conduct research with scientific integrity. Sponsors, institutions, and even investigators may fail to give adequate attention to these issues in the negotiation of CSAs. Despite the key role of CSAs in structuring ethically important aspects of research, they remain largely unregulated and unreviewed for adherence to ethical norms. Academic institutions routinely enter into research contracts that fail to meet adequate (...) ethical standards. This is a failing that can have serious consequences.Accordingly, it is necessary that some independent body have the authority both to review research contracts for compliance with norms of subject protection and ethical integrity, and to reject studies that fail to meet ethical standards. Such review should take place prior to the start of research, not later. Because of its expertise and authority, the institutional ethics review board is the appropriate body to undertake such review. Much recent commentary has focused on contractual restrictions on the investigator’s freedom to publish research findings. The Olivieri experience, and that of other investigators, has brought freedom of publication issues into sharp focus. Clinical study agreements also raise a number of other ethical issues relating to human subjects and research integrity, however, including disclosures relating to patient safety, data analysis and reporting, budget, confidentiality, and premature termination of the study. This paper describes the ethical issues at stake in structuring such agreements and suggests ethical standards to guide institutional ethics review. (shrink)

This essay addresses the question whether artificial speakers can perform speech acts in the technical sense of that term common in the philosophy of language. We here argue that under certain conditions artificial speakers can perform speech acts so understood. After explaining some of the issues at stake in these questions, we elucidate a relatively uncontroversial way in which machines can communicate, namely through what we call verbal signaling. But verbal signaling is not sufficient for the performance of a speech (...) act. To explain the difference, we elucidate the notion of a speech act developed by Austin in the mid-twentieth century and then discuss Strawson’s influential proposal for how that notion may be related to Grice’s conception of speaker meaning. We then refine Strawson’s synthesis in light of Armstrong’s reconceptualization of speaker meaning in terms of objectives rather than intentions. We next extend this conception of speech acts to the cases of recorded, proxy, and conditional speech acts. On this basis, we propose that a characteristic role for artificial speakers is as proxies in the performance of speech acts on behalf of their human creators. We also consider two objections to our position, and compare our approach with others: while other authors appeal to notions such as “quasi-assertion,” we offer a sharp characterization of what artificial speakers can do that does not impute intentions or similarly controversial powers to them. We conclude by raising doubts that our strategy can be applied to speech acts generally. (shrink)

The fifteen selections in this volume are collected around the thesis that many of the foundations and tenets of empiricism are mistaken and must be either rejected outright or radically revised. To introduce these essays, Morick briefly traces the development of modern empiricism from what he considers its source in Hume’s theory of knowledge through the phenomenalist stage to the present conception of empiricism, one of whose basic principles continues to be the fundamental role of observation in the acquisition of (...) knowledge: perception provides the foundation of empirical knowledge. It is particularly this "foundation picture" which has been denounced by many contemporary critics of empiricism as both oversimplified and misleading. The critics, including those in philosophy of language, philosophy of science, and scientists themselves, have proposed three related objections to this notion. The first is that rather than drawing a sharp distinction between observation claims and theoretical claims, observation claims must be understood in terms of a network of background assumptions. The second objection holds that it is this network of assumptions which bestows the very meaning on observation claims. Consequently, an observation term such as "red" will not maintain a fixed meaning throughout various changes in theories. Further, since the objection also covers observation words, the notion of ostensive words is rejected. The final objection is that our observations themselves should be looked upon as interpretations arising from these background assumptions rather than merely barren perceptions, isolated from one’s beliefs and preconceptions. The selections, most of which are well-known, specify these and other critical arguments and revisions. They are arranged into three slightly overlapping sections: "Empiricism and Ontology", "Empiricism and Science", and "Empiricism and Linguistics". Considering the purpose and scope of the book, the contributions have been appropriately chosen. An eight-page annotated bibliography is included.—B. G. H. (shrink)

The aim of Nordenstam’s capable but compact book is to examine the analytic-synthetic distinction and its relationship to empiricism in light of the criticisms expressed by W. V. Quine’s "Two Dogmas of Empiricism," M. G. White’s "The Analytic and the Synthetic: An Untenable Dualism," and N. Goodman’s "On Likeness of Meaning." Nordenstam cites Pasch’s summary of the controversy: "Empiricism presupposes a sharp distinction between analytic and synthetic statements. There is no sharp distinction between analytic and synthetic statements in natural languages (...) but only in artificial languages. But the artificial language approach is incompatible with empiricism. Therefore, empiricism has to be abandoned, or at least it has to be modified." In addressing this argument, Nordenstam begins with an explication of some of the basic concepts: the various interpretations of the principle of analyticity, the gradualist positions of Quine et al., the principle of empiricism, and the relationship between these two principles. From this analysis he concludes that one can legitimately hold the principle of empiricism and still reject the principle of analyticity, thereby denying the first assumption of the above argument. Focusing attention on the opposition to the analytic-synthetic distinction, he introduces a number of criticisms by Quine et al. of some twelve common definitions of "analytic statement" involving the notions of synonymy, state-descriptions, and semantical rules of artificial languages. Here Nordenstam’s suggestion is that the resultant criteria of analyticity and synonymy demanded by Quine et al. are excessively stringent. (shrink)

SummaryThe reviewer welcomes Von Mises' book as a most valuable contribution to the nowadays so badly needed clarifying of philosophical terminology. The author confesses himself to positivism, but his work bears a far more psychological and significal stamp than those of most present positivists.SummaryReviewer objects to the in his opinion far too subjective, emotional and metaphorical way of reasoning, followed in some respects by the author, but appreciates nevertheless many sharp and critical remarks scattered all over the book.

A central theme in the scholarly literature on Enlightenment Europe concerns the increased focus on the role of reason in the development of European thought, especially in the development of the new science by the natural philosophers. As a consequence, there is a tendency in both philosophical scholarship and teaching to bind philosophy and science tightly together. While there is certainly much that is correct in this approach, one motivation for pluralizing philosophy’s past is that this story leaves out a (...) great deal that is important in Enlightenment views of reason. We argue, using as an example the work of figures like Margaret Cavendish, that reason was significantly broader in scope—and that developments in science were paralleled by equally important advances in music, art, literature, medicine, philosophy, and other areas. In recognizing the lack of a sharp boundary between these areas, an inclusive canon of Enlightenment philosophy gives us this richer notion of reason. Integrating figures such as Cavendish into the canon helps us to see that the narrow focus on the scientific version of reason within Enlightenment scholarship creates a false distinction between science and the humanities and misses out on the humanistic ends for which we engage in philosophy. (shrink)

Descartes made a sharp distinction between matter and mind. But he also thought that the two interact with one another. Is such interaction possible, however, without either a materialist reduction of mind to matter or an idealist (phenomenalist) reduction of matter to mind? These questions overshadow the Western tradition in metaphysics from the time of Descartes to present times. The book makes an effort to stay clear of reductivist views of the two Cartesian substances. It defends a dualistic psycho-physical parallel (...) theory which reconciles freedom of action with determinism in nature. Basic problems in perception theory are also discussed, with special emphasis on hearing and sound. Because of the intrinsic interest of the subject and the author's non-technical presentation of it, the book should appeal to all readers with a serious interest in philosophy and psychology. (shrink)